A recent study states that Obstructive Sleep Apnea-OSA is linked independently to Diabetic Peripheral neuropathy-DPN in people suffering from Type 2 Diabetes Mellitus-T2DM. The severity of DPN is closely associated with the extent of OSA and severity of nocturnal hypoxemia.
The leading author, Abd Tahrani MD and clinical lecturer in diabetes and endocrinology at University of Birmingham, UK stated that since OSA is associated with oxidative stress and inflammation, their team hypothesized that it might be associated with peripheral neuropathy in patients suffering from Type 2 Diabetes as well.
In all, 234 adults with T2DM participated in the study. Michigan Neuropathy Screening instrument was used and a home based cardio-respiratory sleep study was conducted in a single night. Monitoring was enabled using a portable multi-channel device.
The results revealed that OSA was independently linked to DPN. The findings did not alter with other factors like age, gender, duration of being diabetic, obesity or estimated glomerular filtration rates. The findings also revealed that OSA was also linked to higher nitrosative or oxidative stress level apart from restricted micro- vascular blood flow regulation.
Both these factors contribute to a potential explanation for a link between OSA and DPN. Dr.Tahrani added that in patients already suffering from T2DM presence of OSA could amplify and aggravate glucose toxicity.
This can have significant implications on tissues susceptible to complications associated with diabetes. The team stated that additional studies are required in this field since current findings are casual.
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